AGPS-PDE11A Fusion FISH Probe
The AGPS-PDE11A Fusion FISH Probe is used to confirm a fusion of the AGPS and PDE11A genes. The fusion of the AGPS and PDE11A genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AGPS-PDE11A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-RERE | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-REOR | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-REGO | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-REGR | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-REAQ | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-ORRE | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-OROR | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-ORGO | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-ORAQ | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-GORE | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-GOOR | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-GOGO | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-GOGR | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-GOAQ | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-GRRE | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-GROR | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-GRGO | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-GRGR | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-GRAQ | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-AQRE | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-AQOR | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-AQGO | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-AQGR | 20 (40 μL) | 200 μL |
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| AGPS-PDE11A-20-AQAQ | 20 (40 μL) | 200 μL |
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AGPS Gene Summary
This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
Gene Name: Alkylglycerone Phosphate Synthase
Chromosome: CHR2: 178257470 -178408564
Locus: 2q31.2
PDE11A Gene Summary
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Phosphodiesterase 11A
Chromosome: CHR2: 178487976 -178973066
Locus: 2q31.2
Gene Diseases
The AGPS PDE11A Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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