AGL-ARHGDIB Fusion FISH Probe
The AGL-ARHGDIB Fusion FISH Probe is used to confirm a fusion of the AGL and ARHGDIB genes. The fusion of the AGL and ARHGDIB genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AGL-ARHGDIB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-RERE | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-REOR | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-REGO | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-REGR | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-REAQ | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-ORRE | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-OROR | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-ORGO | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-ORAQ | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-GORE | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-GOOR | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-GOGO | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-GOGR | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-GOAQ | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-GRRE | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-GROR | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-GRGO | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-GRGR | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-GRAQ | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-AQRE | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-AQOR | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-AQGO | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-AQGR | 20 (40 μL) | 200 μL |
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| AGL-ARHGDIB-20-AQAQ | 20 (40 μL) | 200 μL |
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AGL Gene Summary
This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
Chromosome: CHR1: 100315639 -100389579
Locus: 1p21.2
ARHGDIB Gene Summary
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
Gene Name: Rho GDP Dissociation Inhibitor Beta
Chromosome: CHR12: 15094949 -15114562
Locus: 12p12.3
Gene Diseases
The AGL ARHGDIB Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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