AGK-BRAF Fusion FISH Probe
The AGK-BRAF Fusion FISH Probe is used to confirm a fusion of the AGK and BRAF genes. The fusion of the AGK and BRAF genes has been associated with Skin Cutaneous Melanoma, and Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AGK-BRAF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-RERE | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-REOR | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-REGO | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-REGR | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-REAQ | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-ORRE | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-OROR | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-ORGO | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-ORAQ | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-GORE | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-GOOR | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-GOGO | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-GOGR | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-GOAQ | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-GRRE | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-GROR | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-GRGO | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-GRGR | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-GRAQ | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-AQRE | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-AQOR | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-AQGO | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-AQGR | 20 (40 μL) | 200 μL |
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| AGK-BRAF-20-AQAQ | 20 (40 μL) | 200 μL |
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BRAF Gene Summary
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Gene Name: B-Raf Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR7: 140433812 -140624564
Locus: 7q34
AGK Gene Summary
The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012]
Gene Name: Acylglycerol Kinase
Chromosome: CHR7: 141251077 -141354209
Locus: 7q34
Gene Diseases
The AGK BRAF Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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