AGFG2-COPS6 Fusion FISH Probe
The AGFG2-COPS6 Fusion FISH Probe is used to confirm a fusion of the AGFG2 and COPS6 genes. The fusion of the AGFG2 and COPS6 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AGFG2-COPS6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-RERE | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-REOR | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-REGO | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-REGR | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-REAQ | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-ORRE | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-OROR | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-ORGO | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-ORAQ | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-GORE | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-GOOR | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-GOGO | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-GOGR | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-GOAQ | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-GRRE | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-GROR | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-GRGO | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-GRGR | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-GRAQ | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-AQRE | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-AQOR | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-AQGO | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-AQGR | 20 (40 μL) | 200 μL |
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| AGFG2-COPS6-20-AQAQ | 20 (40 μL) | 200 μL |
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AGFG2 Gene Summary
This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]
Gene Name: ArfGAP With FG Repeats 2
Chromosome: CHR7: 100136833 -100165843
Locus: 7q22.1
COPS6 Gene Summary
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]
Gene Name: COP9 Signalosome Subunit 6
Chromosome: CHR7: 99686582 -99689822
Locus: 7q22.1
Gene Diseases
The AGFG2 COPS6 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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