AGAP3-RELN Fusion FISH Probe
The AGAP3-RELN Fusion FISH Probe is used to confirm a fusion of the AGAP3 and RELN genes. The fusion of the AGAP3 and RELN genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AGAP3-RELN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-RERE | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-REOR | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-REGO | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-REGR | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-REAQ | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-ORRE | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-OROR | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-ORGO | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-ORAQ | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-GORE | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-GOOR | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-GOGO | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-GOGR | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-GOAQ | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-GRRE | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-GROR | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-GRGO | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-GRGR | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-GRAQ | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-AQRE | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-AQOR | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-AQGO | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-AQGR | 20 (40 μL) | 200 μL |
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| AGAP3-RELN-20-AQAQ | 20 (40 μL) | 200 μL |
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RELN Gene Summary
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Reelin
Chromosome: CHR7: 103112230 -103629963
Locus: 7q22.1
AGAP3 Gene Summary
This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]
Gene Name: ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 3
Chromosome: CHR7: 150783825 -150841523
Locus: 7q36.1
Gene Diseases
The AGAP3 RELN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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