AGAP2-CYP27B1 Fusion FISH Probe
The AGAP2-CYP27B1 Fusion FISH Probe is used to confirm a fusion of the AGAP2 and CYP27B1 genes. The fusion of the AGAP2 and CYP27B1 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AGAP2-CYP27B1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-RERE | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-REOR | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-REGO | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-REGR | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-REAQ | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-ORRE | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-OROR | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-ORGO | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-ORAQ | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-GORE | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-GOOR | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-GOGO | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-GOGR | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-GOAQ | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-GRRE | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-GROR | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-GRGO | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-GRGR | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-GRAQ | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-AQRE | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-AQOR | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-AQGO | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-AQGR | 20 (40 μL) | 200 μL |
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| AGAP2-CYP27B1-20-AQAQ | 20 (40 μL) | 200 μL |
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CYP27B1 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]
Gene Name: Cytochrome P450 Family 27 Subfamily B Member 1
Chromosome: CHR12: 58156116 -58160976
Locus: 12q14.1
AGAP2 Gene Summary
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 2
Chromosome: CHR12: 58118075 -58135944
Locus: 12q14.1
Gene Diseases
The AGAP2 CYP27B1 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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