AGAP1-ERBB4 Fusion FISH Probe
The AGAP1-ERBB4 Fusion FISH Probe is used to confirm a fusion of the AGAP1 and ERBB4 genes. The fusion of the AGAP1 and ERBB4 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AGAP1-ERBB4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-RERE | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-REOR | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-REGO | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-REGR | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-REAQ | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-ORRE | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-OROR | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-ORGO | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-ORAQ | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-GORE | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-GOOR | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-GOGO | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-GOGR | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-GOAQ | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-GRRE | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-GROR | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-GRGO | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-GRGR | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-GRAQ | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-AQRE | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-AQOR | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-AQGO | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-AQGR | 20 (40 μL) | 200 μL |
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| AGAP1-ERBB4-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB4 Gene Summary
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 4
Chromosome: CHR2: 212240441 -213403352
Locus: 2q34
AGAP1 Gene Summary
This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1
Chromosome: CHR2: 236402735 -237034120
Locus: 2q37.2
Gene Diseases
The AGAP1 ERBB4 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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