AGAP1-AANAT Fusion FISH Probe
The AGAP1-AANAT Fusion FISH Probe is used to confirm a fusion of the AGAP1 and AANAT genes. The fusion of the AGAP1 and AANAT genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AGAP1-AANAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-RERE | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-REOR | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-REGO | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-REGR | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-REAQ | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-ORRE | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-OROR | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-ORGO | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-GORE | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-GOOR | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-GOGO | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-GOGR | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-GRRE | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-GROR | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-GRGO | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-GRGR | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-AQRE | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-AQOR | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-AQGO | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-AQGR | 20 (40 μL) | 200 μL |
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| AGAP1-AANAT-20-AQAQ | 20 (40 μL) | 200 μL |
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AANAT Gene Summary
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Name: Aralkylamine N-acetyltransferase
Chromosome: CHR17: 74449432 -74466199
Locus: 17q25.1
AGAP1 Gene Summary
This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1
Chromosome: CHR2: 236402735 -237034120
Locus: 2q37.2
Gene Diseases
The AGAP1 AANAT Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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