AFF1-PAQR3 Fusion FISH Probe
The AFF1-PAQR3 Fusion FISH Probe is used to confirm a fusion of the AFF1 and PAQR3 genes. The fusion of the AFF1 and PAQR3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AFF1-PAQR3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-RERE | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-REOR | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-REGO | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-REGR | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-REAQ | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-ORRE | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-OROR | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-ORGO | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-ORAQ | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-GORE | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-GOOR | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-GOGO | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-GOGR | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-GOAQ | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-GRRE | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-GROR | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-GRGO | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-GRGR | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-GRAQ | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-AQRE | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-AQOR | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-AQGO | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-AQGR | 20 (40 μL) | 200 μL |
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| AFF1-PAQR3-20-AQAQ | 20 (40 μL) | 200 μL |
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AFF1 Gene Summary
This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Name: AF4/FMR2 Family Member 1
Chromosome: CHR4: 87856153 -88062206
Locus: 4q21.3-q22.1
PAQR3 Gene Summary
This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Gene Name: Progestin And AdipoQ Receptor Family Member 3
Chromosome: CHR4: 79839093 -79860582
Locus: 4q21.21
Gene Diseases
The AFF1 PAQR3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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