AFF1-GAST Fusion FISH Probe
The AFF1-GAST Fusion FISH Probe is used to confirm a fusion of the AFF1 and GAST genes. The fusion of the AFF1 and GAST genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AFF1-GAST-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-RERE | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-REOR | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-REGO | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-REGR | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-REAQ | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-ORRE | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-OROR | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-ORGO | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-ORAQ | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-GORE | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-GOOR | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-GOGO | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-GOGR | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-GOAQ | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-GRRE | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-GROR | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-GRGO | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-GRGR | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-GRAQ | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-AQRE | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-AQOR | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-AQGO | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-AQGR | 20 (40 μL) | 200 μL |
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| AFF1-GAST-20-AQAQ | 20 (40 μL) | 200 μL |
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GAST Gene Summary
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]
Gene Name: Gastrin
Chromosome: CHR17: 39868612 -39872221
Locus: 17q21.2
AFF1 Gene Summary
This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Name: AF4/FMR2 Family Member 1
Chromosome: CHR4: 87856153 -88062206
Locus: 4q21.3-q22.1
Gene Diseases
The AFF1 GAST Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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