AES-TNNT1 Fusion FISH Probe
The AES-TNNT1 Fusion FISH Probe is used to confirm a fusion of the AES and TNNT1 genes. The fusion of the AES and TNNT1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AES-TNNT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-RERE | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-REOR | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-REGO | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-REGR | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-REAQ | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-ORRE | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-OROR | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-ORGO | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-GORE | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-GOOR | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-GOGO | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-GOGR | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-GRRE | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-GROR | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-GRGO | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-GRGR | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-AQRE | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-AQOR | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-AQGO | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-AQGR | 20 (40 μL) | 200 μL |
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| AES-TNNT1-20-AQAQ | 20 (40 μL) | 200 μL |
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AES Gene Summary
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Amino-terminal Enhancer Of Split
Chromosome: CHR19: 3052907 -3062964
Locus: 19p13.3
TNNT1 Gene Summary
This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Troponin T1, Slow Skeletal Type
Chromosome: CHR19: 55644160 -55660606
Locus: 19q13.42
Gene Diseases
The AES TNNT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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