ADSL-PVALB Fusion FISH Probe
The ADSL-PVALB Fusion FISH Probe is used to confirm a fusion of the ADSL and PVALB genes. The fusion of the ADSL and PVALB genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADSL-PVALB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-RERE | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-REOR | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-REGO | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-REGR | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-REAQ | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-ORRE | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-OROR | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-ORGO | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-GORE | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-GOOR | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-GOGO | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-GOGR | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-GRRE | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-GROR | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-GRGO | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-GRGR | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-AQRE | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-AQOR | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-AQGO | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-AQGR | 20 (40 μL) | 200 μL |
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| ADSL-PVALB-20-AQAQ | 20 (40 μL) | 200 μL |
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ADSL Gene Summary
The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Name: Adenylosuccinate Lyase
Chromosome: CHR22: 40742503 -40762575
Locus: 22q13.1
PVALB Gene Summary
The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Parvalbumin
Chromosome: CHR22: 37196744 -37215517
Locus: 22q12.3
Gene Diseases
The ADSL PVALB Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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