ADSL-CDH18 Fusion FISH Probe
The ADSL-CDH18 Fusion FISH Probe is used to confirm a fusion of the ADSL and CDH18 genes. The fusion of the ADSL and CDH18 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADSL-CDH18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-RERE | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-REOR | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-REGO | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-REGR | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-REAQ | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-ORRE | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-OROR | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-ORGO | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-GORE | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-GOOR | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-GOGO | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-GOGR | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-GRRE | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-GROR | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-GRGO | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-GRGR | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-AQRE | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-AQOR | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-AQGO | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-AQGR | 20 (40 μL) | 200 μL |
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| ADSL-CDH18-20-AQAQ | 20 (40 μL) | 200 μL |
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ADSL Gene Summary
The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Name: Adenylosuccinate Lyase
Chromosome: CHR22: 40742503 -40762575
Locus: 22q13.1
CDH18 Gene Summary
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Name: Cadherin 18
Chromosome: CHR5: 19473154 -19988353
Locus: 5p14.3
Gene Diseases
The ADSL CDH18 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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