ADRBK2-EP300 Fusion FISH Probe
The ADRBK2-EP300 Fusion FISH Probe is used to confirm a fusion of the ADRBK2 and EP300 genes. The fusion of the ADRBK2 and EP300 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADRBK2-EP300-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-RERE | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-REOR | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-REGO | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-REGR | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-REAQ | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-ORRE | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-OROR | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-ORGO | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-GORE | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-GOOR | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-GOGO | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-GOGR | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-GRRE | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-GROR | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-GRGO | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-GRGR | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-AQRE | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-AQOR | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-AQGO | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-AQGR | 20 (40 μL) | 200 μL |
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| ADRBK2-EP300-20-AQAQ | 20 (40 μL) | 200 μL |
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EP300 Gene Summary
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Gene Name: E1A Binding Protein P300
Chromosome: CHR22: 41488613 -41576081
Locus: 22q13.2
Gene Diseases
The ADRBK2 EP300 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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