ADNP-NFATC2 Fusion FISH Probe
The ADNP-NFATC2 Fusion FISH Probe is used to confirm a fusion of the ADNP and NFATC2 genes. The fusion of the ADNP and NFATC2 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADNP-NFATC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-RERE | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-REOR | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-REGO | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-REGR | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-REAQ | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-ORRE | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-OROR | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-ORGO | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-GORE | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-GOOR | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-GOGO | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-GOGR | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-GRRE | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-GROR | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-GRGO | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-GRGR | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-AQRE | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-AQOR | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-AQGO | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-AQGR | 20 (40 μL) | 200 μL |
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| ADNP-NFATC2-20-AQAQ | 20 (40 μL) | 200 μL |
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NFATC2 Gene Summary
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
Gene Name: Nuclear Factor Of Activated T-cells 2
Chromosome: CHR20: 50007764 -50179168
Locus: 20q13.2
ADNP Gene Summary
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Name: Activity Dependent Neuroprotector Homeobox
Chromosome: CHR20: 49506882 -49547527
Locus: 20q13.13
Gene Diseases
The ADNP NFATC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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