ADNP-MMP24 Fusion FISH Probe
The ADNP-MMP24 Fusion FISH Probe is used to confirm a fusion of the ADNP and MMP24 genes. The fusion of the ADNP and MMP24 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADNP-MMP24-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-RERE | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-REOR | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-REGO | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-REGR | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-REAQ | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-ORRE | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-OROR | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-ORGO | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-GORE | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-GOOR | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-GOGO | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-GOGR | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-GRRE | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-GROR | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-GRGO | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-GRGR | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-AQRE | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-AQOR | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-AQGO | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-AQGR | 20 (40 μL) | 200 μL |
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| ADNP-MMP24-20-AQAQ | 20 (40 μL) | 200 μL |
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MMP24 Gene Summary
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). [provided by RefSeq, Feb 2016]
Gene Name: Matrix Metallopeptidase 24
Chromosome: CHR20: 33814538 -33864804
Locus: 20q11.22
ADNP Gene Summary
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Name: Activity Dependent Neuroprotector Homeobox
Chromosome: CHR20: 49506882 -49547527
Locus: 20q13.13
Gene Diseases
The ADNP MMP24 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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