ADNP-GHRH Fusion FISH Probe
The ADNP-GHRH Fusion FISH Probe is used to confirm a fusion of the ADNP and GHRH genes. The fusion of the ADNP and GHRH genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADNP-GHRH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-RERE | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-REOR | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-REGO | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-REGR | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-REAQ | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-ORRE | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-OROR | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-ORGO | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-GORE | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-GOOR | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-GOGO | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-GOGR | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-GRRE | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-GROR | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-GRGO | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-GRGR | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-AQRE | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-AQOR | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-AQGO | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-AQGR | 20 (40 μL) | 200 μL |
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| ADNP-GHRH-20-AQAQ | 20 (40 μL) | 200 μL |
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GHRH Gene Summary
This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Growth Hormone Releasing Hormone
Chromosome: CHR20: 35879489 -35885299
Locus: 20q11.23
ADNP Gene Summary
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Name: Activity Dependent Neuroprotector Homeobox
Chromosome: CHR20: 49506882 -49547527
Locus: 20q13.13
Gene Diseases
The ADNP GHRH Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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