ADNP-DPM1 Fusion FISH Probe
The ADNP-DPM1 Fusion FISH Probe is used to confirm a fusion of the ADNP and DPM1 genes. The fusion of the ADNP and DPM1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADNP-DPM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-RERE | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-REOR | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-REGO | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-REGR | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-REAQ | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-ORRE | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-OROR | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-ORGO | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-GORE | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-GOOR | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-GOGO | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-GOGR | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-GRRE | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-GROR | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-GRGO | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-GRGR | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-AQRE | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-AQOR | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-AQGO | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-AQGR | 20 (40 μL) | 200 μL |
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| ADNP-DPM1-20-AQAQ | 20 (40 μL) | 200 μL |
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DPM1 Gene Summary
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Gene Name: Dolichyl-phosphate Mannosyltransferase Subunit 1, Catalytic
Chromosome: CHR20: 49551404 -49575060
Locus: 20q13.13
ADNP Gene Summary
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Name: Activity Dependent Neuroprotector Homeobox
Chromosome: CHR20: 49506882 -49547527
Locus: 20q13.13
Gene Diseases
The ADNP DPM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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