ADNP-DDX27 Fusion FISH Probe
The ADNP-DDX27 Fusion FISH Probe is used to confirm a fusion of the ADNP and DDX27 genes. The fusion of the ADNP and DDX27 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADNP-DDX27-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-RERE | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-REOR | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-REGO | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-REGR | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-REAQ | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-ORRE | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-OROR | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-ORGO | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-GORE | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-GOOR | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-GOGO | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-GOGR | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-GRRE | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-GROR | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-GRGO | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-GRGR | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-AQRE | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-AQOR | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-AQGO | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-AQGR | 20 (40 μL) | 200 μL |
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| ADNP-DDX27-20-AQAQ | 20 (40 μL) | 200 μL |
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ADNP Gene Summary
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Name: Activity Dependent Neuroprotector Homeobox
Chromosome: CHR20: 49506882 -49547527
Locus: 20q13.13
DDX27 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]
Gene Name: DEAD-box Helicase 27
Chromosome: CHR20: 47835831 -47860614
Locus: 20q13.13
Gene Diseases
The ADNP DDX27 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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