ADNP-BMP7 Fusion FISH Probe
The ADNP-BMP7 Fusion FISH Probe is used to confirm a fusion of the ADNP and BMP7 genes. The fusion of the ADNP and BMP7 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADNP-BMP7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-RERE | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-REOR | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-REGO | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-REGR | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-REAQ | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-ORRE | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-OROR | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-ORGO | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-GORE | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-GOOR | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-GOGO | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-GOGR | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-GRRE | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-GROR | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-GRGO | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-GRGR | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-AQRE | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-AQOR | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-AQGO | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-AQGR | 20 (40 μL) | 200 μL |
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| ADNP-BMP7-20-AQAQ | 20 (40 μL) | 200 μL |
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BMP7 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]
Gene Name: Bone Morphogenetic Protein 7
Chromosome: CHR20: 55743808 -55841707
Locus: 20q13.31
ADNP Gene Summary
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Name: Activity Dependent Neuroprotector Homeobox
Chromosome: CHR20: 49506882 -49547527
Locus: 20q13.13
Gene Diseases
The ADNP BMP7 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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