ADK-SIRT1 Fusion FISH Probe
The ADK-SIRT1 Fusion FISH Probe is used to confirm a fusion of the ADK and SIRT1 genes. The fusion of the ADK and SIRT1 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADK-SIRT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-RERE | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-REOR | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-REGO | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-REGR | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-REAQ | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-ORRE | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-OROR | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-ORGO | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-GORE | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-GOOR | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-GOGO | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-GOGR | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-GRRE | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-GROR | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-GRGO | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-GRGR | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-AQRE | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-AQOR | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-AQGO | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-AQGR | 20 (40 μL) | 200 μL |
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| ADK-SIRT1-20-AQAQ | 20 (40 μL) | 200 μL |
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ADK Gene Summary
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Adenosine Kinase
Chromosome: CHR10: 75910942 -76469061
Locus: 10q11-q24
SIRT1 Gene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Gene Name: Sirtuin 1
Chromosome: CHR10: 69644426 -69678147
Locus: 10q21.3
Gene Diseases
The ADK SIRT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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