ADD1-SH3BP2 Fusion FISH Probe
The ADD1-SH3BP2 Fusion FISH Probe is used to confirm a fusion of the ADD1 and SH3BP2 genes. The fusion of the ADD1 and SH3BP2 genes has been associated with Ovarian Serous Cystadenocarcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADD1-SH3BP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-RERE | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-REOR | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-REGO | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-REGR | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-REAQ | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-ORRE | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-OROR | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-ORGO | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-GORE | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-GOOR | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-GOGO | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-GOGR | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-GRRE | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-GROR | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-GRGO | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-GRGR | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-AQRE | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-AQOR | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-AQGO | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-AQGR | 20 (40 μL) | 200 μL |
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| ADD1-SH3BP2-20-AQAQ | 20 (40 μL) | 200 μL |
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ADD1 Gene Summary
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]
Gene Name: Adducin 1
Chromosome: CHR4: 2845583 -2931802
Locus: 4p16.3
SH3BP2 Gene Summary
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Name: SH3 Domain Binding Protein 2
Chromosome: CHR4: 2794749 -2842823
Locus: 4p16.3
Gene Diseases
The ADD1 SH3BP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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