ADD1-ATP2B4 Fusion FISH Probe
The ADD1-ATP2B4 Fusion FISH Probe is used to confirm a fusion of the ADD1 and ATP2B4 genes. The fusion of the ADD1 and ATP2B4 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADD1-ATP2B4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-RERE | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-REOR | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-REGO | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-REGR | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-REAQ | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-ORRE | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-OROR | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-ORGO | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-GORE | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-GOOR | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-GOGO | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-GOGR | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-GRRE | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-GROR | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-GRGO | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-GRGR | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-AQRE | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-AQOR | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-AQGO | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-AQGR | 20 (40 μL) | 200 μL |
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| ADD1-ATP2B4-20-AQAQ | 20 (40 μL) | 200 μL |
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ADD1 Gene Summary
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]
Gene Name: Adducin 1
Chromosome: CHR4: 2845583 -2931802
Locus: 4p16.3
ATP2B4 Gene Summary
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: ATPase Plasma Membrane Ca2+ Transporting 4
Chromosome: CHR1: 203595914 -203713209
Locus: 1q32.1
Gene Diseases
The ADD1 ATP2B4 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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