ADAMTS17-PCDHA8 Fusion FISH Probe
The ADAMTS17-PCDHA8 Fusion FISH Probe is used to confirm a fusion of the ADAMTS17 and PCDHA8 genes. The fusion of the ADAMTS17 and PCDHA8 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAMTS17-PCDHA8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-RERE | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-REOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-REGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-REGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-OROR | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-GORE | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-GROR | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-PCDHA8-20-AQAQ | 20 (40 μL) | 200 μL |
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PCDHA8 Gene Summary
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Gene Name: Protocadherin Alpha 8
Chromosome: CHR5: 140220906 -140391929
Locus: 5q31.3
ADAMTS17 Gene Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
Gene Name: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17
Chromosome: CHR15: 100511642 -100882183
Locus: 15q26.3
Gene Diseases
The ADAMTS17 PCDHA8 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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