ADAMTS17-NCF4 Fusion FISH Probe
The ADAMTS17-NCF4 Fusion FISH Probe is used to confirm a fusion of the ADAMTS17 and NCF4 genes. The fusion of the ADAMTS17 and NCF4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAMTS17-NCF4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-RERE | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-REOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-REGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-REGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-OROR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GORE | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GROR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-AQAQ | 20 (40 μL) | 200 μL |
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NCF4 Gene Summary
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Neutrophil Cytosolic Factor 4
Chromosome: CHR22: 37257029 -37274059
Locus: 22q12.3
ADAMTS17 Gene Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
Gene Name: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17
Chromosome: CHR15: 100511642 -100882183
Locus: 15q26.3
Gene Diseases
The ADAMTS17 NCF4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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