ADAMTS16-TERT Fusion FISH Probe
The ADAMTS16-TERT Fusion FISH Probe is used to confirm a fusion of the ADAMTS16 and TERT genes. The fusion of the ADAMTS16 and TERT genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAMTS16-TERT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-RERE | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-REOR | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-REGO | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-REGR | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-OROR | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-GORE | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-GROR | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAMTS16-TERT-20-AQAQ | 20 (40 μL) | 200 μL |
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TERT Gene Summary
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
Gene Name: Telomerase Reverse Transcriptase
Chromosome: CHR5: 1253286 -1295162
Locus: 5p15.33
ADAMTS16 Gene Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016]
Gene Name: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 16
Chromosome: CHR5: 5140442 -5320412
Locus: 5p15.32
Gene Diseases
The ADAMTS16 TERT Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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