ADAM9-RNF170 Fusion FISH Probe
The ADAM9-RNF170 Fusion FISH Probe is used to confirm a fusion of the ADAM9 and RNF170 genes. The fusion of the ADAM9 and RNF170 genes has been associated with Lung Squamous Cell Carcinoma, and Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAM9-RNF170-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-RERE | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-REOR | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-REGO | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-REGR | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-OROR | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-GORE | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-GROR | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAM9-RNF170-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAM9 Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
Gene Name: ADAM Metallopeptidase Domain 9
Chromosome: CHR8: 38854504 -38962779
Locus: 8p11.22
RNF170 Gene Summary
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Name: Ring Finger Protein 170
Chromosome: CHR8: 42704779 -42751866
Locus: 8p11.21
Gene Diseases
The ADAM9 RNF170 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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