ADAM9-HTRA4 Fusion FISH Probe
The ADAM9-HTRA4 Fusion FISH Probe is used to confirm a fusion of the ADAM9 and HTRA4 genes. The fusion of the ADAM9 and HTRA4 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAM9-HTRA4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-RERE | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-REOR | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-REGO | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-REGR | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-OROR | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-GORE | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-GROR | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAM9-HTRA4-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAM9 Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
Gene Name: ADAM Metallopeptidase Domain 9
Chromosome: CHR8: 38854504 -38962779
Locus: 8p11.22
HTRA4 Gene Summary
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
Gene Name: HtrA Serine Peptidase 4
Chromosome: CHR8: 38831667 -38846181
Locus: 8p11.22
Gene Diseases
The ADAM9 HTRA4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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