ADAM23-CERKL Fusion FISH Probe
The ADAM23-CERKL Fusion FISH Probe is used to confirm a fusion of the ADAM23 and CERKL genes. The fusion of the ADAM23 and CERKL genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAM23-CERKL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-RERE | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-REOR | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-REGO | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-REGR | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-OROR | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-GORE | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-GROR | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAM23-CERKL-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAM23 Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]
Gene Name: ADAM Metallopeptidase Domain 23
Chromosome: CHR2: 207308367 -207482679
Locus: 2q33.3
CERKL Gene Summary
This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.[provided by RefSeq, May 2010]
Gene Name: Ceramide Kinase Like
Chromosome: CHR2: 182401400 -182521834
Locus: 2q31.3
Gene Diseases
The ADAM23 CERKL Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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