ADAM18-LSM1 Fusion FISH Probe
The ADAM18-LSM1 Fusion FISH Probe is used to confirm a fusion of the ADAM18 and LSM1 genes. The fusion of the ADAM18 and LSM1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAM18-LSM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-RERE | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-REOR | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-REGO | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-REGR | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-OROR | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-GORE | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-GROR | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAM18-LSM1-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAM18 Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: ADAM Metallopeptidase Domain 18
Chromosome: CHR8: 39442086 -39587583
Locus: 8p11.22
LSM1 Gene Summary
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]
Gene Name: LSM1 Homolog, MRNA Degradation Associated
Chromosome: CHR8: 38020858 -38034026
Locus: 8p11.23
Gene Diseases
The ADAM18 LSM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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