ACVR2A-CASP8 Fusion FISH Probe
The ACVR2A-CASP8 Fusion FISH Probe is used to confirm a fusion of the ACVR2A and CASP8 genes. The fusion of the ACVR2A and CASP8 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACVR2A-CASP8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-RERE | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-REOR | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-REGO | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-REGR | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-REAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-ORRE | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-OROR | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-ORGO | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-GORE | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-GOOR | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-GOGO | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-GOGR | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-GRRE | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-GROR | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-GRGO | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-GRGR | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-AQRE | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-AQOR | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-AQGO | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-AQGR | 20 (40 μL) | 200 μL |
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| ACVR2A-CASP8-20-AQAQ | 20 (40 μL) | 200 μL |
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ACVR2A Gene Summary
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
Gene Name: Activin A Receptor Type 2A
Chromosome: CHR2: 148602569 -148688393
Locus: 2q22.3-q23.1
CASP8 Gene Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Gene Name: Caspase 8
Chromosome: CHR2: 202098165 -202152434
Locus: 2q33.1
Gene Diseases
The ACVR2A CASP8 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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