ACVR2A-AKT3 Fusion FISH Probe
The ACVR2A-AKT3 Fusion FISH Probe is used to confirm a fusion of the ACVR2A and AKT3 genes. The fusion of the ACVR2A and AKT3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACVR2A-AKT3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-RERE | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-REOR | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-REGO | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-REGR | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-REAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-ORRE | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-OROR | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-ORGO | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-GORE | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-GOOR | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-GOGO | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-GOGR | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-GRRE | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-GROR | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-GRGO | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-GRGR | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-AQRE | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-AQOR | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-AQGO | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-AQGR | 20 (40 μL) | 200 μL |
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| ACVR2A-AKT3-20-AQAQ | 20 (40 μL) | 200 μL |
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ACVR2A Gene Summary
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
Gene Name: Activin A Receptor Type 2A
Chromosome: CHR2: 148602569 -148688393
Locus: 2q22.3-q23.1
AKT3 Gene Summary
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: AKT Serine/threonine Kinase 3
Chromosome: CHR1: 243651534 -244006584
Locus: 1q43-q44
Gene Diseases
The ACVR2A AKT3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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