ACVR1B-CS Fusion FISH Probe
The ACVR1B-CS Fusion FISH Probe is used to confirm a fusion of the ACVR1B and CS genes. The fusion of the ACVR1B and CS genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACVR1B-CS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-RERE | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-REOR | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-REGO | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-REGR | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-REAQ | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-ORRE | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-OROR | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-ORGO | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-GORE | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-GOOR | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-GOGO | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-GOGR | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-GRRE | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-GROR | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-GRGO | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-GRGR | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-AQRE | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-AQOR | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-AQGO | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-AQGR | 20 (40 μL) | 200 μL |
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| ACVR1B-CS-20-AQAQ | 20 (40 μL) | 200 μL |
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ACVR1B Gene Summary
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Gene Name: Activin A Receptor Type 1B
Chromosome: CHR12: 52345450 -52390863
Locus: 12q13.13
CS Gene Summary
The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2008]
Gene Name: Citrate Synthase
Chromosome: CHR12: 56665482 -56694175
Locus: 12q13.3
Gene Diseases
The ACVR1B CS Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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