ACTN4-YIF1B Fusion FISH Probe
The ACTN4-YIF1B Fusion FISH Probe is used to confirm a fusion of the ACTN4 and YIF1B genes. The fusion of the ACTN4 and YIF1B genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTN4-YIF1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-RERE | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-REOR | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-REGO | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-REGR | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-OROR | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-GORE | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-GROR | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTN4-YIF1B-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTN4 Gene Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Gene Name: Actinin Alpha 4
Chromosome: CHR19: 39138266 -39221171
Locus: 19q13.2
YIF1B Gene Summary
The Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein (YIF1B) gene is located on chr19 :38794199-38806606 at 19q13.2.
Gene Name: Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein
Chromosome: CHR19: 38794199 -38806606
Locus: 19q13.2
Gene Diseases
The ACTN4 YIF1B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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