ACTL6A-ALG3 Fusion FISH Probe
The ACTL6A-ALG3 Fusion FISH Probe is used to confirm a fusion of the ACTL6A and ALG3 genes. The fusion of the ACTL6A and ALG3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTL6A-ALG3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-RERE | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-REOR | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-REGO | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-REGR | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-OROR | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-GORE | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-GROR | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTL6A-ALG3-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTL6A Gene Summary
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Actin Like 6A
Chromosome: CHR3: 179280707 -179306193
Locus: 3q26.33
ALG3 Gene Summary
This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Gene Name: ALG3, Alpha-1,3- Mannosyltransferase
Chromosome: CHR3: 183960116 -183967313
Locus: 3q27.1
Gene Diseases
The ACTL6A ALG3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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