ACTG1-USP7 Fusion FISH Probe
The ACTG1-USP7 Fusion FISH Probe is used to confirm a fusion of the ACTG1 and USP7 genes. The fusion of the ACTG1 and USP7 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACTG1-USP7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-RERE | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-REOR | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-REGO | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-OROR | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-GORE | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| ACTG1-USP7-20-AQAQ | 20 (40 μL) | 200 μL |
|
ACTG1 Gene Summary
Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Name: Actin Gamma 1
Chromosome: CHR17: 79476996 -79479892
Locus: 17q25.3
USP7 Gene Summary
The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016]
Gene Name: Ubiquitin Specific Peptidase 7
Chromosome: CHR16: 8985950 -9057341
Locus: 16p13.2
Gene Diseases
The ACTG1 USP7 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|