ACTG1-STAT6 Fusion FISH Probe
The ACTG1-STAT6 Fusion FISH Probe is used to confirm a fusion of the ACTG1 and STAT6 genes. The fusion of the ACTG1 and STAT6 genes has been associated with Uterine Corpus Endometrial Carcinoma, and Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTG1-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTG1-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTG1 Gene Summary
Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Name: Actin Gamma 1
Chromosome: CHR17: 79476996 -79479892
Locus: 17q25.3
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The ACTG1 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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