ACTG1-DDX21 Fusion FISH Probe
The ACTG1-DDX21 Fusion FISH Probe is used to confirm a fusion of the ACTG1 and DDX21 genes. The fusion of the ACTG1 and DDX21 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTG1-DDX21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-RERE | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-REOR | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-REGO | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-REGR | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-OROR | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-GORE | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-GROR | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTG1-DDX21-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTG1 Gene Summary
Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Name: Actin Gamma 1
Chromosome: CHR17: 79476996 -79479892
Locus: 17q25.3
DDX21 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Gene Name: DExD-box Helicase 21
Chromosome: CHR10: 70715891 -70744279
Locus: 10q22.1
Gene Diseases
The ACTG1 DDX21 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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