ACTB-SAFB Fusion FISH Probe
The ACTB-SAFB Fusion FISH Probe is used to confirm a fusion of the ACTB and SAFB genes. The fusion of the ACTB and SAFB genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTB-SAFB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-RERE | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-REOR | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-REGO | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-REGR | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-OROR | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-GORE | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-GROR | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTB-SAFB-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTB Gene Summary
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017]
Gene Name: Actin Beta
Chromosome: CHR7: 5566778 -5570232
Locus: 7p22.1
SAFB Gene Summary
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
Gene Name: Scaffold Attachment Factor B
Chromosome: CHR19: 5623045 -5668489
Locus: 19p13.3
Gene Diseases
The ACTB SAFB Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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