ACTB-CELA3A Fusion FISH Probe
The ACTB-CELA3A Fusion FISH Probe is used to confirm a fusion of the ACTB and CELA3A genes. The fusion of the ACTB and CELA3A genes has been associated with Pancreatic Adenocarcinoma, and Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTB-CELA3A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-RERE | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-REOR | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-REGO | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-REGR | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-OROR | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-GORE | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-GROR | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTB-CELA3A-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTB Gene Summary
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017]
Gene Name: Actin Beta
Chromosome: CHR7: 5566778 -5570232
Locus: 7p22.1
CELA3A Gene Summary
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]
Gene Name: Chymotrypsin Like Elastase Family Member 3A
Chromosome: CHR1: 22328148 -22339035
Locus: 1p36.12
Gene Diseases
The ACTB CELA3A Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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