ACSL3-SMARCAL1 Fusion FISH Probe
The ACSL3-SMARCAL1 Fusion FISH Probe is used to confirm a fusion of the ACSL3 and SMARCAL1 genes. The fusion of the ACSL3 and SMARCAL1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACSL3-SMARCAL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-RERE | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-REOR | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-REGO | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-REGR | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-REAQ | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-ORRE | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-OROR | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-ORGO | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-GORE | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-GOOR | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-GOGO | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-GOGR | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-GRRE | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-GROR | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-GRGO | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-GRGR | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-AQRE | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-AQOR | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-AQGO | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-AQGR | 20 (40 μL) | 200 μL |
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| ACSL3-SMARCAL1-20-AQAQ | 20 (40 μL) | 200 μL |
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ACSL3 Gene Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Acyl-CoA Synthetase Long Chain Family Member 3
Chromosome: CHR2: 223725731 -223808119
Locus: 2q36.1
SMARCAL1 Gene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. [provided by RefSeq, Jul 2008]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like 1
Chromosome: CHR2: 217277136 -217347774
Locus: 2q35
Gene Diseases
The ACSL3 SMARCAL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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