ACSL3-PHGDH Fusion FISH Probe
The ACSL3-PHGDH Fusion FISH Probe is used to confirm a fusion of the ACSL3 and PHGDH genes. The fusion of the ACSL3 and PHGDH genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACSL3-PHGDH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-RERE | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-REOR | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-REGO | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-REGR | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-REAQ | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-ORRE | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-OROR | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-ORGO | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-GORE | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-GOOR | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-GOGO | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-GOGR | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-GRRE | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-GROR | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-GRGO | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-GRGR | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-AQRE | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-AQOR | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-AQGO | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-AQGR | 20 (40 μL) | 200 μL |
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| ACSL3-PHGDH-20-AQAQ | 20 (40 μL) | 200 μL |
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ACSL3 Gene Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Acyl-CoA Synthetase Long Chain Family Member 3
Chromosome: CHR2: 223725731 -223808119
Locus: 2q36.1
PHGDH Gene Summary
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
Gene Name: Phosphoglycerate Dehydrogenase
Chromosome: CHR1: 120254418 -120286849
Locus: 1p12
Gene Diseases
The ACSL3 PHGDH Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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