ACP2-MRPL48 Fusion FISH Probe
The ACP2-MRPL48 Fusion FISH Probe is used to confirm a fusion of the ACP2 and MRPL48 genes. The fusion of the ACP2 and MRPL48 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACP2-MRPL48-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-RERE | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-REOR | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-REGO | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-REGR | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-REAQ | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-ORRE | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-OROR | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-ORGO | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-GORE | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-GOOR | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-GOGO | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-GOGR | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-GRRE | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-GROR | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-GRGO | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-GRGR | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-AQRE | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-AQOR | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-AQGO | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-AQGR | 20 (40 μL) | 200 μL |
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| ACP2-MRPL48-20-AQAQ | 20 (40 μL) | 200 μL |
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ACP2 Gene Summary
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
Gene Name: Acid Phosphatase 2, Lysosomal
Chromosome: CHR11: 47260852 -47270457
Locus: 11p12-p11
MRPL48 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Gene Name: Mitochondrial Ribosomal Protein L48
Chromosome: CHR11: 73498916 -73575656
Locus: 11q13.4
Gene Diseases
The ACP2 MRPL48 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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