ACP2-CD74 Fusion FISH Probe
The ACP2-CD74 Fusion FISH Probe is used to confirm a fusion of the ACP2 and CD74 genes. The fusion of the ACP2 and CD74 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACP2-CD74-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-RERE | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-REOR | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-REGO | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-OROR | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-GORE | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| ACP2-CD74-20-AQAQ | 20 (40 μL) | 200 μL |
|
ACP2 Gene Summary
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
Gene Name: Acid Phosphatase 2, Lysosomal
Chromosome: CHR11: 47260852 -47270457
Locus: 11p12-p11
CD74 Gene Summary
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: CD74 Molecule
Chromosome: CHR5: 149781199 -149792499
Locus: 5q33.1
Gene Diseases
The ACP2 CD74 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|