ACOT11-C8B Fusion FISH Probe
The ACOT11-C8B Fusion FISH Probe is used to confirm a fusion of the ACOT11 and C8B genes. The fusion of the ACOT11 and C8B genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACOT11-C8B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-RERE | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-REOR | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-REGO | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-REGR | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-REAQ | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-ORRE | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-OROR | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-ORGO | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-GORE | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-GOOR | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-GOGO | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-GOGR | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-GRRE | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-GROR | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-GRGO | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-GRGR | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-AQRE | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-AQOR | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-AQGO | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-AQGR | 20 (40 μL) | 200 μL |
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| ACOT11-C8B-20-AQAQ | 20 (40 μL) | 200 μL |
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C8B Gene Summary
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Gene Name: Complement C8 Beta Chain
Chromosome: CHR1: 57394882 -57431688
Locus: 1p32.2
ACOT11 Gene Summary
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Gene Name: Acyl-CoA Thioesterase 11
Chromosome: CHR1: 55013806 -55100417
Locus: 1p32.3
Gene Diseases
The ACOT11 C8B Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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