ACO2-PRR5 Fusion FISH Probe
The ACO2-PRR5 Fusion FISH Probe is used to confirm a fusion of the ACO2 and PRR5 genes. The fusion of the ACO2 and PRR5 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACO2-PRR5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-RERE | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-REOR | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-REGO | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-REGR | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-REAQ | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-ORRE | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-OROR | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-ORGO | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-GORE | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-GOOR | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-GOGO | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-GOGR | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-GRRE | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-GROR | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-GRGO | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-GRGR | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-AQRE | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-AQOR | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-AQGO | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-AQGR | 20 (40 μL) | 200 μL |
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| ACO2-PRR5-20-AQAQ | 20 (40 μL) | 200 μL |
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ACO2 Gene Summary
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
Gene Name: Aconitase 2
Chromosome: CHR22: 41865128 -41924993
Locus: 22q13.2
PRR5 Gene Summary
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]
Gene Name: Proline Rich 5
Chromosome: CHR22: 45064426 -45133561
Locus: 22q13.31
Gene Diseases
The ACO2 PRR5 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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