ACO2-ARHGAP8 Fusion FISH Probe
The ACO2-ARHGAP8 Fusion FISH Probe is used to confirm a fusion of the ACO2 and ARHGAP8 genes. The fusion of the ACO2 and ARHGAP8 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACO2-ARHGAP8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-RERE | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-REOR | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-REGO | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-REGR | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-REAQ | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-ORRE | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-OROR | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-ORGO | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-GORE | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-GOOR | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-GOGO | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-GOGR | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-GRRE | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-GROR | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-GRGO | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-GRGR | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-AQRE | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-AQOR | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-AQGO | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-AQGR | 20 (40 μL) | 200 μL |
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| ACO2-ARHGAP8-20-AQAQ | 20 (40 μL) | 200 μL |
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ACO2 Gene Summary
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
Gene Name: Aconitase 2
Chromosome: CHR22: 41865128 -41924993
Locus: 22q13.2
ARHGAP8 Gene Summary
This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]
Gene Name: Rho GTPase Activating Protein 8
Chromosome: CHR22: 45148437 -45258664
Locus: 22q13.31
Gene Diseases
The ACO2 ARHGAP8 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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