ACLY-NEUROD2 Fusion FISH Probe
The ACLY-NEUROD2 Fusion FISH Probe is used to confirm a fusion of the ACLY and NEUROD2 genes. The fusion of the ACLY and NEUROD2 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACLY-NEUROD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-RERE | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-REOR | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-REGO | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-REGR | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-REAQ | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-ORRE | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-OROR | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-ORGO | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-GORE | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-GOOR | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-GOGO | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-GOGR | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-GRRE | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-GROR | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-GRGO | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-GRGR | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-AQRE | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-AQOR | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-AQGO | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-AQGR | 20 (40 μL) | 200 μL |
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| ACLY-NEUROD2-20-AQAQ | 20 (40 μL) | 200 μL |
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ACLY Gene Summary
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
Gene Name: ATP Citrate Lyase
Chromosome: CHR17: 40023178 -40075272
Locus: 17q21.2
NEUROD2 Gene Summary
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008]
Gene Name: Neuronal Differentiation 2
Chromosome: CHR17: 37760020 -37764175
Locus: 17q12
Gene Diseases
The ACLY NEUROD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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