ACLY-DNAJC7 Fusion FISH Probe
The ACLY-DNAJC7 Fusion FISH Probe is used to confirm a fusion of the ACLY and DNAJC7 genes. The fusion of the ACLY and DNAJC7 genes has been associated with Breast Invasive Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACLY-DNAJC7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-RERE | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-REOR | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-REGO | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-REGR | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-REAQ | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-ORRE | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-OROR | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-ORGO | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-GORE | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-GOOR | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-GOGO | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-GOGR | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-GRRE | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-GROR | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-GRGO | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-GRGR | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-AQRE | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-AQOR | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-AQGO | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-AQGR | 20 (40 μL) | 200 μL |
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| ACLY-DNAJC7-20-AQAQ | 20 (40 μL) | 200 μL |
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ACLY Gene Summary
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
Gene Name: ATP Citrate Lyase
Chromosome: CHR17: 40023178 -40075272
Locus: 17q21.2
DNAJC7 Gene Summary
This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Gene Name: DnaJ Heat Shock Protein Family (Hsp40) Member C7
Chromosome: CHR17: 40128438 -40169715
Locus: 17q21.2
Gene Diseases
The ACLY DNAJC7 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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