ACACB-UNG Fusion FISH Probe
The ACACB-UNG Fusion FISH Probe is used to confirm a fusion of the ACACB and UNG genes. The fusion of the ACACB and UNG genes has been associated with Breast Invasive Carcinoma, Skin Cutaneous Melanoma, Colon Adenocarcinoma, Skin Cutaneous Melanoma, Rectum Adenocarcinoma, and Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACACB-UNG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-RERE | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-REOR | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-REGO | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-REGR | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-REAQ | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-ORRE | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-OROR | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-ORGO | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-GORE | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-GOOR | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-GOGO | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-GOGR | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-GRRE | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-GROR | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-GRGO | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-GRGR | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-AQRE | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-AQOR | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-AQGO | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-AQGR | 20 (40 μL) | 200 μL |
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| ACACB-UNG-20-AQAQ | 20 (40 μL) | 200 μL |
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ACACB Gene Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Acetyl-CoA Carboxylase Beta
Chromosome: CHR12: 109577201 -109706030
Locus: 12q24.11
UNG Gene Summary
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
Gene Name: Uracil DNA Glycosylase
Chromosome: CHR12: 109535398 -109548798
Locus: 12q24.11
Gene Diseases
The ACACB UNG Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Skin Cutaneous Melanoma |
| Colon Adenocarcinoma |
| Skin Cutaneous Melanoma |
| Rectum Adenocarcinoma |
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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